According to compatibility chart - yes. Just double check file version as well.
Here are my few experiences while upgrading, better if you can have a look, and add you experience also if you find any issues.
I have downloaded the update and followed the instructions:
From EPiServer Deployment Center i run the following:
EPiServer Commerce 18.104.22.168 (CMS 6.1.379.0)
EPiServer Commerce Sample 1.1 (CMS 6.1.379.0)
In the instructions I found this link confusing:
As I shown above I upgraded EPiServer but the link describes how to reinstall EPiServer from start.
The referenced dll files in my EPiServer Commerce Site must be updated to the new version. I have a question if any more changes must be done to the project?
Is EPiServer Commerce 22.214.171.124 (CMS 6.1.379) the same as EPiServer Commerce 1 R2 SP2?