The problem is that sometimes when you try to edit some input (in current it is int), the autosave event is not triggered so you can not publish changes afterwards. Please see the screenshot below.
Which version of EPiServer are you using?
I had the same problem with EPi 8.0. After upgrade to the latest version of EPi (8.6.0), the problem's gone.
Thanks for the quick reply. Will schedule an update to the latest EPiServer version. Currently we are using episerver 7.5. This is due to complexity in updating enterprise applications.