Hi Bjørn, I think the content/region replacement is by necessity performed really early during the initialization of a page. I have not attempted what you are suggesting, but have you looked into using multiple frameworks rather than switching design by selecting a certain region? If you were to place your 5 different layouts in 5 different frameworks, you can use the EPiServer ContentFrameworkSelector web control to allow some/all of your page templates to support some/all of these different frameworks... That way you could specify in detail how each page type should appear in each of the different layouts. "A normal page in layout A should send X content to region A1 and Y content to region A2 (in framework A)." "A normal page in layout B should send Z and W content to region B1 (in framework B)." Which layout/framework to use would be decided at runtime by the ContentFrameworkSelector control (I believe it can be based on information in the URL, personalized settings, etc).