Error message is: Object reference not set to an instance of an object. Description: An unhandled exception occurred during the execution of the current web request. Please review the stack trace for more information about the error and where it originated in the code. Exception Details: System.NullReferenceException: Object reference not set to an instance of an object. Source Error: An unhandled exception was generated during the execution of the current web request. Information regarding the origin and location of the exception can be identified using the exception stack trace below. Stack Trace: [NullReferenceException: Object reference not set to an instance of an object.] System.Web.HttpContext.RewritePath(VirtualPath filePath, VirtualPath pathInfo, String queryString, Boolean setClientFilePath) +40 System.Web.HttpContext.RewritePath(String filePath, String pathInfo, String queryString, Boolean setClientFilePath) +51 EPiServer.Web.UrlRewriteModuleBase.BeginRequestEventHandler(Object sender, EventArgs e) +585 System.Web.SyncEventExecutionStep.System.Web.HttpApplication.IExecutionStep.Execute() +92 System.Web.HttpApplication.ExecuteStep(IExecutionStep step, Boolean& completedSynchronously) +64

I experience the same error. I have a supportcase with EPiServer Support, but have not come to any conclusion yet.

We had the same problem. Then I applied all the latest updates/security patches for .NET framework from Windows Update, and after the updates it started working.

If anyone are interested this fixed it: http://support.microsoft.com/kb/928365 You will get it if you update .Net framework using "Windows Update".