Hi,
Yes it is possible, but not supported. We do not treat the resource key structure for this area part of our public API. So if you do change this it is not 100% it will work in the future.

If you e.g. are running AlloyMvc you can add this resource key structure to Views.xml

<episerver>
<cms>
<homeview>
<title>My Custom title</title>
</homeview>
</cms>
</episerver>

When the resources are applied using the FileXmlLocalizationProvider, which is the case in AlloyMVC, the files are sorted on file name.
So to make it more likely that you resource key will be applied you can rename the file to e.g. _Views.xml.