We have setup deploy from our Azure DevOps Server to EPiServer DXP. Last week the deploys started failing:

msdeploy.exe failed with return code: 4294967295

A colleague sent a support-case for this and got anwers:

• We received a few other cases where the exact same error started appearing yesterday, so we have opened up an investigation with Microsoft to investigate this further.
• This issue is occurring because msdeploy is trying to use TLS 1.0 and the integration web app is set to TLS 1.2. There is a possible workaround to for the use of TLS 1.2, see below article. You can try this workaround while we work with Microsoft support for resolution. Also, can you tell us what version of Visual Studio you are using? https://www.brechtbaekelandt.net/blog/post/visual-studio-webdeploy-fails-with-error-the-underlying-connection-was-closed-an-unexpected-error-occurred-on-a-send

Before I tried the solution from the link above I tried a "Repair" of "Microsoft Web Deploy 4.0" in "Control Panel\All Control Panel Items\Programs and Features" on the build server.

After that the deploy worked again.

If this solved it, or if Microsoft or EPiServer fixed something during the weekend I dont know.

But if you still have the problem you could try a repair.

Regards Hans