Anyone seen this before? What special permissions does the "IUSR" need?

System.ComponentModel.Win32Exception: Access is denied 

System.Diagnostics.ProcessManager.OpenProcess(Int32 processId, Int32 access, Boolean throwIfExited) +724600 System.Diagnostics.NtProcessManager.GetModuleInfos(Int32 processId, Boolean firstModuleOnly) +126 System.Diagnostics.Process.get_MainModule() +96 EPiServer.Global.get_IsWebDevWebServer() +26 EPiServer.Core.Licensing.Test() +40 EPiServer.LocalPageStore.CheckLicense() +67 EPiServer.LocalPageStore.GetPage(PageReference pageLink, ILanguageSelector selector, AccessLevel access) +34 EPiServer.DataFactory.GetPage(PageReference pageLink, ILanguageSelector selector, AccessLevel access) +334 EPiServer.Web.FriendlyUrlRewriteProvider.GetPageFromStartByPath(String path, LanguageBranch languageBranch, AccessLevel access) +794 EPiServer.Web.FriendlyUrlRewriteProvider.ConvertToInternalInternal(UrlBuilder url, Object& internalObject) +459 EPiServer.Web.FriendlyUrlRewriteProvider.ConvertToInternal(UrlBuilder url, Object& internalObject) +439 EPiServer.Web.UrlRewriteModule.HttpUrlRewriteToInternal(UrlBuilder url) +345 EPiServer.Web.UrlRewriteModuleBase.BeginRequestEventHandler(Object sender, EventArgs e) +234 System.Web.SyncEventExecutionStep.System.Web.HttpApplication.IExecutionStep.Execute() +92 System.Web.HttpApplication.ExecuteStep(IExecutionStep step, Boolean& completedSynchronously) +64