Is it possible to add a (gui) plugin at runtime?

I understand that I can implement icustompluginloader and determine there which plugins to load, however the plugin is not discoverable by episerver because its situated in another assembly which loaded into the appdomain at runtime and therefore not available when episerver scans for plugin attributes on startup.

somethink like :

var plugin = typeof(myplugin)

Episerver.plugins.Add(plugin)

on subsequent page request this plugin will now be executed.