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Yes, you can run the database scripts to achieve this. Have a look at below blog posts by Bjorn Isaksen
http://baisaksen.net/episerver/upgrade-episerver-database-manually-5-6
and
http://baisaksen.net/episerver/login-failed-for-user
Thanks for your reply.
The problem was that I was using an AD user to authenticate against Sql server. After creating a regular Sql server login and defining it in the web.config, the installation went ok.
I'm trying to upgrade to R2 using Episerver deployment center, but I get the error message: Login failed for user 'domain\user'.
But I can connect to the database with this user when I run the application.
Can I upgrade the database in some other way than using deployment center? Is it some way I can just run the scripts directly against sql server?