I think the easiest way to handle something like this would be to use a taxonomy and/or metadata mapping on the content widgets in question and then swap them based on that piece.

For example with taxonomy, you could have a node for "Homepage" and under that you would have "Default", "Region A", "Region B" and simply select the needed content from there to display it. Alternatively with metadata you can set individual content references on the properties for each region(s) as properties on the page and simply pull from there.

This is probably the easiest/fastest way to handle changing out the code in this fashion. Though I'm sure someone would likely have a more robust idea.

Thanks Dustin.

That sounds like a good starting point. When we add content we could assign a category and then show/hide the widget depending on region/location. We are currently in exploratory mode at the moment and will be looking to develop a solution over the next week, so I'd imagine I will be back on here with questions.